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NAT and JAH Associates to Collaborate

Boston, April 14, 2011 - Neo-Advent Technologies, LLC, Littleton, MA and JAH Associates, LLC, Wayne, PA have entered into a strategic collaboration that will combine the expertise of both companies in offering a comprehensive panel of integrated services covering a wide range of pre-clinical drug and medical devices development tasks. Services comprise design and execution of complete preclinical development programs including medicinal chemistry, API scale-up, drug formulation, toxicology, and drug metabolism and pharmacokinetic studies with comprehensive in-house analytical and bio-analytical support. Additional expertise includes the formation of comprehensive regulatory strategies for pre-clinical and clinical development, protocol development, study placement and monitoring, report writing, reviews of preclinical programs, and preparation of regulatory documents, including Investigator Brochures and IND applications. JAH Associates’ Principal, Jeff Handler, said: “We are very pleased to begin collaboration with NAT who have built up an impressive lab operation capable of efficiently addressing, under the same roof, many practical issues in drug formulation, chemistry and analytical and bio-analytical support encountered on the drug and medical device development pathway where we previously needed multiple vendors of solutions and services.” NAT President Nelson Landrau said: “Jeff and his team brings an enormous value to the table with their hands-on experience in project management, toxicology, pharmacology, and regulatory aspects. Our clients will also gain significant benefits by creating and executing development plans that achieve their business goals rapidly and in a cost-effective manner.”

NAT Presented at PITTCON 2011 in Atlanta

Boston, January 28, 2011 – Neo-Advent Technologies, LLC will be present at PITTCON 2011 in Atlanta, Booth No. 5158, to showcase its offerings in drug formulation and bioanalytical services alongside with over a thousand of companies participating in this major industry event. PITTCON is the world's largest annual conference and exposition for the laboratory science. It offers the latest technology and instrumentation, a diverse technical programs including presentations, posters, as well as a vast array of educational courses and networking sessions. This venue provides an opportunity to exchange innovative ideas for scientists from around the world.

NAT Filed a Patent Application on Novel Smart Hydrogels for Drug Delivery

Littleton, October 10, 2010 - Neo-Advent Technologies, LLC reached a major milestone in its program on development of polymer-based smart hydrogels that are responsive to the environmental stimulus such as temperature, ionic strength, pH, and other factors. The Company filed a provisional patent application regarding a proprietary method of introducing thiol groups into hyaluronic acid (HA). The thiolated HA precursors are low viscosity solutions stable at pH=3-4 that are easy to handle and apply. Gelation occurs with a pH adjustment to 7.0-7.4 in presence of oxygen from air that oxidizes thiol groups with a formation of the disulfide cross-links. The gelation time and properties of the gel can be exquisitely regulated by the thiol content, HA concentration, pH, and temperature. Developed technology avoids a byproduct formation, exothermic reactions and potential toxicity inherent to many hydrogel cross-linkers.

NAT Began Offering GLP-compliant Thermal Stability Studies

Littleton, September 5, 2010 - Neo-Advent Technologies, LLC extended to GLP compliant its service offering in thermal stability studies of the active pharmaceutical ingredients (APIs) and finished products. The Company provides protocol development, testing and evaluation under the variety of conditions following ICH guideline including controlled humidity, as well as custom cyclic conditions. The range of testing products involves APIs, tablets, topical, and parenteral formulations. Complemented by the wide range of the analytical quality control techniques including HPLC and LC/MS, the testing program can meet most stringent demands of the customers in a timely manner.

NAT Initiates Services Using a 4000 QTRAP LC/MS/MS System

Littleton, May 10, 2010 – Neo-Advent Technologies, LLC completed the installation of the AB SCIEX 4000 QTRAP·LC/MS/MS System, a state-of-the-art hybrid triple quadrupole/linear ion trap mass spectrometer, a powerful tool to further extend the range of NAT’s R&D capabilities and services into drug discovery and development, metabolite identification, contaminant testing, and proteomic applications including post-translationally modified proteins discovery, protein identification, and biomarker validation. The system will enable high-sensitivity full-scan MS, MS/MS, and MS3 with high-selectivity from true triple quadrupole precursor ion (PI) and neutral loss (NL) scans; perform multiple-reaction monitoring (MRM) for quantitation using high-sensitivity triple quadrupole; identify, characterize, and quantitate metabolites more quickly and easily; identify and sequence post-translationally modified (PTM) peptides automatically in a single LC/MS/MS run; facilitate hypothesis-driven biomarker discovery and validation.

NAT Filed a Patent Application on Novel Smart Hydrogels for Drug Delivery

BOSTON, November 8, 2007 - Neo-Advent Technologies, LLC is selected to be a key co-development sub-contractor on a grant awarded to Reactive Innovations, LLC from the National Science Foundation to formulate, design, and produce a thin film flexible barrier coating specifically for Flexible OLEDs (FOLEDs).

One of the biggest advantages of OLEDs over other display technologies is the ability to fabricate them on flexible substrates, mainly because of the efficient, emissive, solid-state nature of the devices and the absence of viewing angle effects. Flexible substrates, including plastics, have several advantages over glass such as ruggedness, robustness, ultra-light weight, conformability and impact resistance. However, use of FOLEDs is hampered by limited lifetime exhibited by these displays, due to ingress of water and oxygen into the device.

The project's efforts will be focused on formulation, design and fabrication a thin flexible film barrier coating specifically for FOLEDs. This technology will enable a flexible coating with outstanding barrier properties that can be applied with standard (non physical/chemical vapor deposition) coating processes. A commercialization partner, Universal Display Corporation, will assist the project by advising on FOLED coating requirements and evaluating barrier coated substrates with the goal of incorporating the barrier coating into their products.

 

BOSTON, May 31, 2007 - Neo-Advent Technologies, LLC is selected to be a key co-development sub-contractor on a grant awarded to Reactive Innovations, LLC from the Centers for Disease Control to develop a new line of scratch resistant, self-cleaning, and anti-fog eyewear to protect citrus crop workers.

The US Department of Health and Human Services in cooperation with the Partnership for Citrus Worker Health has identified an urgent need for improved protective eyewear for citrus workers. Studies of serious occupational eye injuries have demonstrated that safety glasses would prevent the majority of injuries, if used. However, worker acceptance is low, primarily because current safety eyewear is poorly suited for harvesting citrus in hot, humid conditions. The specific drawbacks of available safety eyewear are that the lenses do not provide the required combination of scratch resistance, self-cleaning capability and anti-fog characteristics.

Neo-Advent Technologies with its teaming partners Reactive Innovations, LLC and Bacou-Dalloz Eye & Face Protection Inc. will formulate, design, and fabricate a scratch resistant, anti-fog/self-cleaning coating to address this issue. New coating will combine the flexibility and adhesion of a polymer with the hardness and chemical resistance of a glass. Potential commercial applications include Rx lens manufacturers, food-packaging developers and suppliers of automotive glass for windshields and mirrors. The Rx lens market represents more than $3 Billion in sales each year. This improved coating technology could revolutionize the transparent substrate marketplace.

 

BOSTON, May 1, 2006 - Neo-Advent Technologies, LLC is selected to be a key co-development sub-contractor on a grant awarded to Reactive Innovations, LLC (RIL) by the Department of Energy to develop a new barrier coating for advanced photovoltaic modules.

The Department of Energy is interested in improving renewable energy technologies such as photovoltaics to allow them to reach their full potential. A critical need for photovoltaic module packaging is the development of barrier coatings to protect solar cells from water and water vapor. Not only must these coatings be impermeable to water vapor, but they must also be optically transparent, stable at high temperatures, unaffected by UV radiation, chemically resistant, and easy to apply giving a low cost. Furthermore, coating adhesion to commonly used polymeric encapsulants and backsheets, such as ethylene vinyl acetate (EVA) and polyvinylflouride (PVF) must be excellent. It is highly desirable to have one material and application technique that would work for all types of solar cells. Neo-Advent Technologies (NAT) and its partners Reactive Innovations, LLC (RIL) and Madico are formulating, designing, and fabricating a photovoltaic device barrier coating (PDBC) for use in renewable energy applications. To accomplish this, the team is developing a new technology by synthesizing novel materials and using them in a unique configuration. This technology will enable a photovoltaic module barrier coating that can be applied without the use of physical/chemical vapor deposition (PVD/CVD) processes. NAT is inventing the chemical formulations of the barrier coating; RIL is designing a system that exhibits exceptional barrier properties while maintaining flexibility and ease of application; Madico is assisting in evaluating the samples and scaling the technology for commercialization.

The outcome of this barrier coating process will provide the government and industry with a coating system that meets or exceeds the performance of presently used coatings and their corresponding pretreatments/primers. The present focus of this technology is toward PV devices/modules although it has a broad scope of applications where outdoor weather protection and barrier coating protection are required. Some of the areas where this technology can be successfully adopted include aircraft, ships, electronics, aerospace, automotive, construction and scratch resistant coatings. Specifically, these markets include food/beverage packaging and barrier technologies for organic light emitting devices.

 

BOSTON, February 16, 2006 - Neo-Advent Technologies, LLC is selected to be a key co-development sub-contractor on a grant awarded to Reactive Innovations, LLC (RIL) by US Navy to develop a radar absorbing and non-skid coating for marine flight decks.

Currently available flight deck coating systems used under normal temperature fluctuations with heavy traffic usage have poor performance in the areas of reduced radar signature return. The Navy requires that new coatings be developed that maintain a high coefficient of friction and excellent adhesion to the decking. Simultaneous with these requirements, the coatings must also absorb radar using radar absorbing materials over the advanced new destroyer, DD(X), design frequencies. Typical of current non-skid coating systems, new coatings with radar absorbing materials must be resistant to sunlight/UV, seawater and shipboard chemicals while demonstrating excellent wear, impact, and corrosion resistance.

Neo-Advent Technologies and Reactive Innovations, LLC are working in conjunction with and R&F Products who will synthesize coatings using a combination of novel components and processing techniques. The first phase of NAT's development contract will demonstrate the feasibility of fabricating non-skid and radar absorbing coatings with later phases finalizing the coating formulation to military specification MIL-PRF-24667B by working with the US Navy, the DD(X) prime contractor, and a commercialization partner, ITW American Safety Technologies.

Beyond military applications, there are a number of applications where a non-skid and radar absorbing coating is needed. Areas where this technology can be successfully adopted include building construction materials such as electromagnetic wave absorption panels and the communications industry that require minimal signal reflection in communication tower platforms.

 
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